![]() ![]() Moreover, myocardial Glu/Tau concentrations are significantly altered during ischemia/reperfusion so as to maintain metabolic and ionic homeostasis in cardiomyocytes. The α-amino acid, glutamate (Glu), and the β-amino acid, taurine (Tau), are both normally present in the myocardium at substantially higher concentrations than in the plasma and in this way differ from other amino acids. While several electrophysiological mechanisms have been proposed to underlie the initiation and perpetuation of AF, the cellular proarrhythmic mechanism of the disorder remains unknown. These data suggest a novel pathophysiological role of Glu and Tau in association with ROS production in paroxysmal AF, providing new insights into the elevated amino acid content in cardiac disease.Ītrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. ![]() Glu and Tau levels both showed significant positive associations with plasma hydroperoxide concentrations. Glu/Tau levels also showed an independent association with AF by multiple logistic regression analysis. Glu/Tau content was significantly higher in patients with AF versus controls (Glu: 79.2 ± 23.9 versus 60.5 ± 25.2 nmol/L Tau: 78.8 ± 19.8 versus 68.5 ± 20.8 nmol/L mean ± standard deviation (SD), p < 0.001 for both). Circulating Glu and Tau levels were measured and correlations between Glu/Tau and ROS levels were examined. Fifty patients with paroxysmal AF and 50 control subjects without a history of AF were consecutively enrolled. Here, we tested the hypothesis that the metabolism of Glu and Tau is altered in association with the generation of reactive oxygen species (ROS) in patients with AF. Glutamate (Glu) and taurine (Tau) are present in the myocardium at substantially higher concentrations than in the plasma, suggesting their active role in myocardium. ![]() Atrial fibrillation (AF) is the most common cardiac arrhythmia, but its proarrhythmic mechanism remains to be elucidated. ![]()
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